Publications

Kensuke Fujii, Kazuma Yamakawa, Yuriko Takeda, Natsuko Okuda, Akira Takasu & Fumihito Ono (2024)
Understanding the pathophysiology of acute critical illness: translational lessons from zebrafish models.
Intensive Care Medicine Experimental, https://doi.org/10.1186/s40635-024-00595-x

Mikoto Nakajo, Shinji Kanda & Yoshitaka Oka (2024)
Involvement of the kisspeptin system in regulation of sexual behaviors in medaka.
iScience 27,108971, https://doi.org/10.1016/j.isci.2024.108971

Yasuhiro Yamamoto, Daisuke Hishikawa & Fumihito Ono (2024)
Trpv4-mediated apoptosis of Leydig cells induced by high temperature regulates sperm development and motility in zebrafish.
Commun Biol 7, 96, https://doi.org/10.1038/s42003-023-05740-y

Souhei Sakata, Fumihito Ono (2023)
Allosteric inhibition of muscle-type nicotinic acetylcholine receptors by a neuromuscular blocking agent pancuronium.
PLOS ONE, https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0292262

Kazumasa Komura, Kensuke Hirosuna, Satoshi Tokushige, Takuya Tsujino, Kazuki Nishimura, Mitsuaki Ishida, Takuo Hayashi, Ayako Ura, Takaya Ohno, Shogo Yamazaki, Keita Nakamori, Shoko Kinoshita, Ryoichi Maenosono, Masahiko Ajiro, Yuki Yoshikawa, Tomoaki Takai, Takeshi Tsutsumi, Kohei Taniguchi, Tomohito Tanaka, Kiyoshi Takahara, Tsuyoshi Konuma, Teruo Inamoto, Yoshinobu Hirose, Fumihito Ono, Yuichi Shiraishi, Akihide Yoshimi & Haruhito Azuma (2023)
The Impact of FGFR3 Alterations on the Tumor Microenvironment and the Efficacy of Immune Checkpoint Inhibitors in Bladder Cancer.
Mol Cancer 22, 185, https://doi.org/10.1186/s12943-023-01897-6

Kazumasa Komura, Satoshi Tokushige, Mitsuaki Ishida, Kensuke Hirosuna, Shogo Yamazaki, Kazuki Nishimura, Masahiko Ajiro, Takaya Ohno, Keita Nakamori, Shoko Kinoshita, Takuya Tsujino, Ryoichi Maenosono, Yuki Yoshikawa, Tomoaki Takai, Takeshi Tsutsumi, Kohei Taniguchi, Tomohito Tanaka, Kiyoshi Takahara, Teruo Inamoto, Yoshinobu Hirose, Fumihito Ono, Yuichi Shiraishi, Akihide Yoshimi, Haruhito Azuma (2023)
Tertiary lymphoid structure and neutrophil–lymphocyte ratio coordinately predict outcome of pembrolizumab.
Cancer Science, 2023;00:1–10, https://doi.org/10.1111/cas.15976

Manami Yamashita, Yoshihiro Egashira, Shuntaro Nakamura, Souhei Sakata & Fumihito Ono (2022)
Receptor subunit compositions underly distinct potencies of a muscle relaxant in fast and slow muscle fibers.
Frontiers in Physiology, section Striated Muscle Physiology, https://doi.org/10.3389/fphys.2022.1026646

Ryu Hashimoto, Masafumi Minoshima, Souhei Sakata, Fumihito Ono, Hirokazu Ishii, Yuki Watakabe, Tomomi Nemoto, Saeko Yanaka, Koichi Kato & Kazuya Kikuchi (2022)
Efficient visible/NIR light-driven uncaging of hydroxylated thiazole orange-based caged compounds in aqueous media.
Chemical Science Vol. 13, issue 25, pp. 7462-7467, DOI: 10.1039/d2sc02364d

Yoshihiro Egashira, Ayane Kumade, Akio Ojida & Fumihito Ono (2022)
Spontaneously Recycling Synaptic Vesicles Constitute Readily Releasable Vesicles in Intact Neuromuscular Synapses.
Journal of Neuroscience, Vol.42, No. 17 pp. 3523-3536, DOI: https://doi.org/10.1523/JNEUROSCI.2005-21.2022

Yoshihiro Egashira, Shutaro Katsurabayashi & Shigeo Takamori (2022)
Quantitative Analysis of Presynaptic Vesicle Luminal pH in Cultured Neurons.
Synaptic Vesicles. Methods in Molecular Biology, Vol. 2417, pp. 45-58, DOI: https://doi.org/10.1007/978-1-0716-1916-2_4

Manami Yamashita & Tetsuya Hori (2022)
A Novel Method to Monitor GABA Loading into Synaptic Vesicles by Combining Patch Pipette Perfusion and Intracellular, Caged-GABA Photolysis in Brain Slice Preparations.
Synaptic Vesicles. Methods in Molecular Biology, Vol. 2417, pp. 113-120, DOI: https://doi.org/10.1007/978-1-0716-1916-2_9

Thomas Fleming, Yukiko Kikuchi, Mikoto Nakajo, Masaya Tachizawa, Tomoaki Inazumi, Soken Tsuchiya, Yukihiko Sugimoto, Daisuke Saito, Mikita Suyama, Yasuyuki Ohkawa, Takashi Baba, Ken-ichirou Morohashi & Kataaki Okubo (2022)
Prostaglandin E2 receptor Ptger4b regulates female-specific peptidergic neurons and female sexual receptivity in medaka.
Communications Biology 5, 1215,
https://doi.org/10.1038/s42003-022-04195-x

Kana Ikegami, Sho Kajihara, Chie Umatani, Mikoto Nakajo, Shinji Kanda & Yoshitaka Oka (2022)
Estrogen upregulates the firing activity of hypothalamic gonadotropin-releasing hormone (GnRH1) neurons in the evening in female medaka.
Journal of Neuroendocrinology, e13101,
https://doi.org/10.1111/jne.13101

Kana Yamamoto, Toshihiko Kuriu, Kensuke Matsumura, Kazuki Nagayasu, Yoshinori Tsurusaki, Noriko Miyake, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Mikiya Fujiwara, Masayuki Baba, Kohei Kitagawa, Tomoya Takemoto, Nanaka Gotoda-Nishimura, Tomohiro Takada, Kaoru Seiriki, Atsuko Hayata-Takano, Atsushi Kasai, Yukio Ago, Satoshi Kida, Kazuhiro Takuma, Fumihito Ono, Naomichi Matsumoto, Ryota Hashimoto, Hitoshi Hashimoto & Takanobu Nakazawa (2021)
Multiple alterations in glutamatergic transmission and dopamine D2 receptor splicing in induced pluripotent stem cell-derived neurons from patients with familial schizophrenia.
Translational Psychiatry vol. 11, Article number: 548, DOI: https://doi.org/10.1038/s41398-021-01676-1

Buntaro Zempo, Natsuko Tanaka, Eriko Daikoku & Fumihito Ono (2021)
High-speed camera recordings uncover previously unidentified elements of zebrafish mating behaviors integral to successful fertilization.
Scientific Reports vol. 11, Article number: 20228, DOI: https://www.nature.com/articles/s41598-021-99638-6

Kazumasa Komura, Teruo Inamoto, Takuya Tsujino, Yusuke Matsui, Tsuyoshi Konuma, Kazuki Nishimura, Taizo Uchimoto, Takeshi Tsutsumi, Tomohisa Matsunaga, Ryoichi Maenosono, Yuki Yoshikawa, Kohei Taniguchi, Tomohito Tanaka, Hirofumi Uehara, Koichi Hirata, Hajime Hirano, Hayahito Nomi, Yoshinobu Hirose, Fumihito Ono & Haruhito Azuma (2021)
Increased BUB1B/BUBR1 expression contributes to aberrant DNA repair activity leading to resistance to DNA-damaging agents.
Oncogene, DOI: https://doi.org/10.1038/s41388-021-02021-y

Buntaro Zempo, Yasuhiro Yamamoto, Tory Williams & Fumihito Ono (2020)
Synaptic silencing of fast muscle is compensated by rewired innervation of slow muscle.
Science Advances 2020 vol. 6, No.15, eaax8382, DOI: 10.1126/sciadv.aax8382

Kensuke Fujii, Koichi Nakajo, Yoshihiro Egashira, Yasuhiro Yamamoto, Kazuya Kitada, Kohei Taniguchi, Masaru Kawai, Hideki Tomiyama, Koichi Kawakami, Kazuhisa Uchiyama & Fumihito Ono (2020)
Gastrointestinal Neurons Expressing HCN4 Regulate Retrograde Peristalsis.
Cell Reports 2020 vol. 30, ISSUE 9, pp.2879-2888.

Daichi Kayo, Buntaro Zempo, Soma Tomihara, Yoshitaka Oka & Shinji Kanda(2019)
Gene knockout analysis reveals essentiality of estrogen receptor β1 (Esr2a) for female reproduction in medaka.
Scientific Reports 2019 vol. 9, Article number: 8868, https://www.nature.com/articles/s41598-019-45373-y.


Yoshiyasu Ono, Yasunori Mori, Yoshihiro Egashira, Kenta Sumiyama & Shigeo Takamori(2019)
Expression of plasma membrane calcium ATPases confers Ca2+/H+ exchange in rodent synaptic vesicles.
Scientific Reports 2019 vol. 9, Article number: 4289, https://www.nature.com/articles/s41598-019-40557-y.

Akira Kawanabe, Masaki Hashimoto, Manami Nishizawa, Kazuhisa Nishizawa, Hirotaka Narita, Tomoko Yonezawa, Yuka Jinno, Souhei Sakata, Atsushi Nakagawa & Yasushi Okamura(2018)
The hydrophobic nature of a novel membrane interface regulates the enzyme activity of a voltage-sensing phosphatase.
eLife 2018;7:e41653, DOI: 10.7554/eLife.41653.


Souhei Sakata& Yasushi Okamura(2018)
Dynamic structural rearrangements and functional regulation of voltage‐sensing phosphatase.
The Journal of Physiology, https://doi.org/10.1113/JP274113.


Yoshihiro Egashira, Yasunori Mori, Yuchio Yanagawa & Shigeo Takamori(2018)
Development of lentiviral vectors for efficient glutamatergic-selective gene expression in cultured hippocampal neurons.
Scientific Reports vol. 8, Article number: 15156, https://doi.org/10.1038/s41598-018-33509-5.


Lin Li, Xiaodong Jiao, Ilaria D'Atri, Fumihito Ono, Ralph Nelson, Chi-Chao Chan, Naoki Nakaya, Zhiwei Ma, Yan Ma, Xiaoying Cai, Longhua Zhang,Siying Lin, Abdul Hameed, Barry A. Chioza, Holly Hardy, Gavin ArnoSarah Hull, Muhammad Imran Khan, James Fasham, Gaurav V. Harlalka, Michel Michaelides, Anthony T. Moore, Zeynep Hande Coban Akdemir, Shalini Jhangiani, James R. Lupski, Frans P. M. Cremers, Raheel Qamar, Ahmed Salman, John Chilton, Jay Self, Radha Ayyagari, Firoz Kabir, Muhammad Asif Naeem, Muhammad Ali, Javed Akram, Paul A. Sieving, Sheikh Riazuddin, Emma L. Baple, S. Amer Riazuddin, Andrew H. Crosby& J. Fielding Hejtmancik(2018)
Mutation in the intracellular chloride channel CLCC1 associated with autosomal recessive retinitis pigmentosa.
PLOS Genetics 2018 Auguest, https://doi.org/10.1371/journal.pgen.1007504.


Yoshihiro Egashira, Buntaro Zempo, Souhei Sakata& Fumihito Ono(2018)
Recent advances in neuromuscular junction research prompted by the zebrafish model.
Current Opinion in Physiology 2018 Vol. 4, pp. 70-75, https://doi.org/10.1016/j.cophys.2018.06.005.


Manami Yamashita, Shin-ya Kawaguchi, Tetsuya Hori& Tomoyuki Takahashi(2018)
Vesicular GABA Uptake Can Be Rate Limiting for Recovery of IPSCs from Synaptic Depression.
Cell Reports Vol.22, Issue 12, pp.3134-3141, DOI: 10.1016/j.celrep.2018.02.080.


Buntaro Zempo, Tomomi Karigo, Shinji Kanda, Yasuhisa Akazome& Yoshitaka Oka(2018)
Morphological Analysis of the Axonal Projections of EGFP-Labeled Esr1-Expressing Neurons in Transgenic Female Medaka.
Endocrinology Vol.159, Issue 2, pp. 1228-1241, DOI: 10.1210/en.2017-00873.

Yoshihiro Egashira& Shigeo Takamori(2017)
Mechanism of vesicular neurotransmitter transport into the synaptic vesicles.
Journal of Japanese Biochemical Society Vol.89, No. 6, pp.856-860, DOI: 10.14952/SEIKAGAKU.2017.890856.


Akiyuki Taruno, Hongxin Sun, Koichi Nakajo, Tatsuro Murakami, Yasuyoshi Ohsaki, Mizuho A. Kido, Fumihito Ono& Yoshinori Marunaka(2017)
Post-translational palmitoylation controls the voltage gating and lipid raft association of the CALHM1 channel.
The Journal of Physiology Vol.595, No. 18, pp. 6121-6145, DOI: 10.1113/JP274164.


Yuka Shiraiwa, Eriko Daikoku, Masahisa Saito, Yui Yamashita, Takaya Abe, Fumihito Ono& Takahiro Kubota(2017)
Measurements of ionic concentrations along with endocochlear potential in wild-type and claudin 14 knockout mice.
Auris Nasus Larynx, https://doi.org/10.1016/j.ani.2017.07.013.


Souhei Sakata, Makoto Matsuda, Akira Kawanabe & Yasushi Okamura(2017)
Domain-to-domain coupling in voltage-sensing phosphatase.
Biophysics and Physicobiology Vol. 14, pp. 85-97, DOI: 10.2142/biophysico.14.0_85.


Meghan Mott, Victor M. Luna, Jee-Young Park, Gerald B. Downes, Kimberly Epley & Ono Fumihito(2017)
Expressing acetylcholine receptors after innervation suppresses spontaneous vesicle release and causes muscle fatigue.
Scientific Reports Vol. 7, No.1674, DOI: 10.1038/s41598-017-01900-3.


Nishino Atsuo & Ono Fumihito(2017)
Neuromuscular synapses in ascidians, fish and higher vertebrates.
Comparative Physiology and Biochemistry Vol. 34, No. 1, pp.12-21. (in Japanese)

Sakata S., Miyawaki N., McCormack T., Arima H., Kawanabe A., Özkucui N., Kurokawa T., Jinno Y., Fujiwara Y., Okumura Y.(2016)
Comparison between mouse and sea urchin orthologs of voltage-gated proton channel suggests role of S3 segment in activation gating.
Biochimica et Biophysica Acta (BBA) - Biomembranes 1858 (12): 2972-2983.


Torvund M., Ma T., Connaughton V., Ono F., Nelson R. (2016)
Cone signals in the monostratified and bistratified amacrine cells of adult zebrafish retina.
Journal of Comparative Neurology DOI: 10.1002/cne. 24107


Sakata S.,Jinno Y., Kawanabe A., Okamura Y. (2016)
Voltage-dependent motion of the catalytic ragion of voltage-sensing phosphatase monitored by a fluorescent amino acid.
PNAS 113 (27):7521-7526.

Luna V., Daikoku E., Ono F. (2015)
“Slow” skeletal muscles across vertebrate species.　
Cell & Bioscience 5: 62, doi:10.1186/s13578-015-0054-6.


Kitazawa K., Kubo Y., Nakajo K. (2015)　
Kv4.2 and Accessory Dipeptidyl Peptidase-like Protein 10 (DPP10)Subunit Preferentially Form a 4:2 (Kv4.2:DPP10)Channel Complex.
Journal of Biological Chemistry 290: 22724-22733.


Nakajo K., Kubo Y. (2015)
KCNQ1 channel modulation by KCNE proteins via the voltage-sensing domain.
Journal of Physiology 593: 2617-2625.


Daikoku E., Saito M., Ono F. (2015)
Zebrafish mutants of the neuromuscular junction:Swimming in the gene pool.
Journal of Physiological Sciences 65: 217-221.


Nishimura T., Sato T., Yamamoto Y., Watakabe I., Ohkawa Y., Suyama M., Kobayashi S. & Tanaka M.(2015)
foxl3 is a germ cell-intrinsic factor involved in sperm-egg fate decision in medaka.
Science 349: 328-331.


Ono F., Daikoku E., Saito M.(2015)
Zebrafish as a model synaptic system.
Journal of Osaka Medical College 74: 1-6. (in Japanese)

Park J., Mott M., Williams T., Ikeda H., Wen H., Linhoff M., Ono F. (2014)
A single mutation in the acetylcholine receptor delta-subunit causes distinct effectsin two types of neuromuscular synapses.
Journal of Neuroscience 34: 10211-10218.


Puhl H., Lu V., Won Y., Sasson Y., Hirsch J., Ono F., Ikeda S. (2014)
Ancient origins of RGK protein function: modulation of voltage-gated calcium channels preceded the protostome and deuterostome split.
PLoS ONE 9: e100694.


Fero K., Bergeron S., Horstick E., Codore H., Li G., Ono F., Dowling J., Burgess H. (2014)
Impaired embryonic motility in dusp27 mutants reveals a developmental defect in myofibril structure.
Disease Models and Mechanisms 7: 289-298.


Nakajo K., Kubo Y. (2014)
Steric hindrance between S4 and S5 of the KCNQ1/KCNE1 channel hampers pore opening.
Nature Communications 5: 4100.


Kitazawa M., Kubo Y., Nakajo K. (2014)
The stoichiometry and biophysical properties of the Kv4 potassium channel complex with K+ channel-interacting protein(KChIP) subunits are variable, depending on the relative expression level.
Journal of Biological Chemistry 289: 17597-17609.


Mutua J., Jinno Y., Sakata S., Okochi Y., Ueno S., Tsutsui H., Kawai T., Iwao Y. & Okamura Y.(2014)
Functional diversity of voltage-sensing phosphatases in two urodele amphibians.
Physiological Reports 2: e12061.


Yamaguchi S., Kurokawa T., Taira I., Aoki N., Sakata S., Okamura Y. & Homma KJ. (2014)
Potential role of voltage-sensing phosphatases in regulation of cell structure through the production of PI(3,4)P2.
Journal of Cellular Physiology 229:422-433.


Sakata S. & Okamura Y. (2014)
Phosphatase activity of the voltage-sensing phosphatase, VSP, shows graded dependence on the extent of activation of the voltage sensor.
Journal of Physiology 592: 899-914.


Kokunai Y., Nakata T., Furuta M., Sakata S., Kimura H., Aiba T., Yoshinaga M., Osaki Y., Nakamori M., Itoh H., Sato T., Kubota T., Kadota K., Shindo K., Mochizuki H., Shimizu W., Horie M., Okamura Y., Ohno K., Takahashi MP.(2014)
A Kir3.4 mutation causes Andersen-Tawil syndrome by an inhibitory effect on Kir2.1.
Neurology 82: 1058-1064.


Takeshita K., Sakata S., Yamashita E., Fujiwara Y., Kawanabe A., Kurokawa T., Okochi Y., Matsuda M., Narita H, Okamura Y. & Nakagawa A. (2014)
X-ray crystal structure of voltage-gated proton channel.
Nature Structural & Molecular Biology 21: 352-357.


Nishimura T., Herpin A., Kimura T., Hara I., Kawasaki T., Nakamura S., Yamamoto Y., Saito TL., Yoshimura J., Morishita S.,Tsukahara T., Kobayashi S., Naruse K., Shigenobu S., Sakai N., Schartl M & Tanaka M. (2014)
Analysis of a novel gene, Sdgc, reveals sex chromosome-dependent differences of medaka germ cells prior to gonad formation. 　
Development 141: 3363-3369.