小野富三人

Yamamoto., Y., Hishikawa, D., Ono, F., Trpv4-mediated apoptosis of Leydig cells induced by high temperature regulates sperm development and motility in zebrafish (2023) Communications Biology in press

 

Sakata, S., Ono, F.,  Allosteric inhibition of muscle-type nicotinic acetylcholine receptors by a neuromuscular blocking agent pancuronium (2023) PLOS One https://doi.org/10.1371/journal.pone.0292262

 

小野富三人　アセチルコリン受容体サブユニットにみる進化　(2023) Clinical Neuroscience 41:1562-1565 (in Japanese)

 

Yoshimi et al. The Impact of FGFR3 Alterations on the Tumor Microenvironment and the Efficacy of Immune Checkpoint Inhibitors in Bladder Cancer (2023) Molecular Cancer 22:185 https://doi.org/10.1186/s12943-023-01897-6

 

Komura, K., Tokushige, S., Ishida, M., Hirosuna, K., Yamazaki , S., Nishimura, K., Ajiro, M., Ohno , T., Nakamori,  K., Kinoshita, S., Tsujino, T., Maenosono, R., Yoshikawa, Y., Takai, T., Tsutsumi, T., Taniguchi, K., Tanaka, T., Takahara, K., Inamoto , T., Hirose, Y., Ono, F., Shiraishi, Y., Yoshimi, A., Azuma, H., Tertiary Lymphoid Structure and Neutrophil-Lymphocyte Ratio Coordinately Predict Outcome of Pembrolizumab (2023) Cancer Science 00:1–10. DOI: 10.1111/cas.15976

 

Yamashita, M., Egashira, Y., Nakamura, S., Sakata, S., Ono, F. Receptor subunit compositions underly distinct potencies of a muscle relaxant in fast and slow muscle fibers (2022) Frontiers in Physiology doi: 10.3389/fphys.2022.1026646

 

西村 太一, 迫田 航次郎, 牛久 敦, 橋本 敦史, 奥田 奈津子, 小野 富三人, 亀甲 博貴, 森 信介　BioVL2データセット: 生化学分野における一人称視点の実験映像への言語アノテーション (2022)自然言語処理　29(4):  1-31 (in Japanese)

 

Yamasaki E, Shimamoto F, Nishikawa H, Goto M, Iwamoto M, Kimura K, Ukimura A, Oosaka N, Taniguchi K, Ono F, Terazawa T, Yamaguchi T, Asaishi K, Ikegami T, Uchiyama K, Nakamura S, Higuchi K. A prospective study regarding efficacy and safety of BNT162b2 vaccine in patients with solid malignancy undergoing systemic chemotherapy (2022) IN VIVO 36:2780-2789. doi: 10.21873/invivo.13015.

 

Hashimoto, R., Minoshima, M., Sakata, S., Ono, F., Ishii, H., Watakabe, Y., Nemoto, T., Yanaka, S., Kato, K., Kikuchi, K. Efficient Visible/NIR Light-driven Uncaging of Hydroxylated Thiazole Orange-based Caged Compounds in Aqueous Media (2022) Chemical Science 13(25): 7462–7467. doi: 10.1039/d2sc02364d

 

Egashira, Y., Kumade, A., Ojima, A., Ono, F. Spontaneously recycling synaptic vesicles constitute readily-releasable vesicles in intact neuromuscular synapses (2022) J Neurosci　42:3523-3536　 https://doi.org/10.1523/JNEUROSCI.2005-21.2022

 

Yamamoto, K., Kuriu, T., Matsumura, K., Nagayasu, K., Tsukusaki, Y. Miyake, N., Yamamori, H., Yasuda, Y., Fujimoto, M., Fujiwara, M., Baba, M., Kitagawa, K., Takemoto, T., Gotoda-Nishimura, N., Takada, T., Seiriki, K., Hayata-Takano, A., Ago, Y., Kida, S., Takuma, K., Ono, F., Matsumoto, N., Hashimoto, R., Hashimoto, H., Nakazawa, T. Multiple alterations in glutamatergic transmission and dopamine D2 receptor splicing in induced pluripotent stem cell-derived neurons from patients with familial schizophrenia (2021) Translational Psychiatry 11:548 https://doi.org/10.1038/s41398-021-01676-1

 

Komura, K., Inamoto, T., Tsujino, T., Matsui, Y., T., Konuma, Nishimura, K., Uchimoto, T., Tsutsumi, T., Matsunaga, T., Maenosono, R., Yoshikawa, Y., Taniguchi, K., Tanaka, T., Uehara, H., Hirata, K., Hirano, H., Nomi, H., Hirose, Y., Ono, F., Azuma, H. (2021)  Increased BUB1B/BUBR1 Expression Contributes to Aberrant DNA Repair Activity Leading to Resistance to DNA Damaging Agents.   Oncogene https://doi.org/10.1038/s41388-021-02021-y

 

Zempo, B., Tanaka, N., Daikoku, E., Ono, F. High-speed camera recordings uncover previously unidentified elements of zebrafish mating behaviors integral to successful fertilization (2021)　 Scientific Reports 11:20228 |

https://doi.org/10.1038/s41598-021-99638-6

 

Zempo B, Yamamoto, Y., Williams, T., Ono, F. (2020) Synaptic silencing of fast muscle is compensated by rewired innervation of slow muscle. Science Advances 6: eaax8382.

 

Fujii, K.,  Nakajo, K., Egashira, Y., Yamamoto, Y., Kitada, K., Taniguchi, K., Kawai, M., Tomiyama, H., Kawakami, K., Uchiyama, K., Ono, F. (2020) Gastrointestinal Neurons Expressing HCN4 Regulate Retrograde Peristalsis. Cell Reports 30: 2879-2888.

 

Li L et al. (3^rd in 41 authors) (2018) Mutation in the intracellular chloride channel CLCC1 associated with autosomal recessive retinitiss pigmentosa. PLoS Genet 14:e1007504.

 

Egashira, Y., Zempo, B., Sakata, S., Ono, F. (2018) Recent advances in neuromuscular junction research prompted by the zebrafish model. Current Opinion in Physiology 04:70-75.

 

Shiraiwa, Y., Daikoku. E., Saito, M., Yamashita, Y., Abe, T., Ono, F., Kubota, T. (2018) Measurements of ionic concentrations along with endocochlear potential in wild-type and claudin 14 KO mice. Auris Nasus Larynx 45:421-426.

 

Taruno. A., Sun, H., Nakajo, K., Murakami, T., Ohsaki, Y., Kido, M., Ono, F., Marunaka, Y. (2017) Post-translational palmitoylation controls the voltage gating and lipid raft association of the CALHM1 channel. Journal of Physiology 595: 6121-6145.

 

Mott, M., Luna, V., Park, J., Downes, G., Epley, K., Ono, F. (2017) Expressing acetylcholine receptors after innervation suppresses spontaneous vesicle release and causes muscle fatigue. Scientific Reports 7: 1674.

 

Nishino, A., Ono, F. (2017) Neuromuscular synapses in ascidians, fish and higher vertebrates.  Comparative Physiology and Biochemistry 34:12-21. (Japanese)

 

Torvund, M., Ma, T., Connaughton, V., Ono, F., Nelson, R. (2016) Cone signals in the monostratified and bistratified amacrine cells of adult zebrafish retina. Journal of Comparative Neurology doi:10.1002/cne.24107.

 

Luna, V., Daikoku, E., Ono, F. (2015) “Slow” muscles across vertebrate species. Cell & Bioscience 5:62.

 

Ono, F., Daikoku, E., Saito, M. (2015) Zebrafish as a model synaptic system. The Journal of Osaka Medical College 74:1-6. (Japanese)

 

Daikoku, E., Saito, M., Ono, F. (2015) Zebrafish mutants of the neuromuscular junction: Swimming in the gene pool. Journal of Physiological Sciences 65: 217-221.

 

Park, J., Mott, M., Williams, T., Ikeda, H., Wen, H., Linhoff, M., Ono, F. (2014) A single mutation in the acetylcholine receptor delta-subunit causes distinct effects in two types of neuromuscular synapses. Journal of Neuroscience 34: 10211-10218.

 

Puhl, H., Lu, V., Won, Y., Sasson, Y., Hirsch, J., Ono, F., Ikeda, S. (2014) Ancient origins of RGK protein function: modulation of voltage-gated calcium channels preceded the protostome and deuterostome split. PLoS ONE 9: e100694.

 

Fero, K., Bergeron, S., Horstick, E., Codore, H., Li, G., Ono, F., Dowling, J., Burgess, H. (2014) Impaired embryonic motility in dusp27 mutants reveals a developmental defect in myofibril structure. Disease Models and Mechanisms 7: 289-298.

 

Ikeda, H., Delargy, A., Yokogawa, T., Urban, J., Burgess, H., Ono, F. (2013) Intrinsic properties of larval zebrafish neurons in ethanol. PLoS ONE 8: e63318.

 

Ono, F. (2013) Big answers from a small fly with a cultured brain. Journal of Physiology 591: 3.

 

Walogorsky, M., Wen, H., Mongeon, R., Urban, J., Ono, F., Mandel, G., Brehm, P. (2012) A zebrafish model for congenital myasthenic syndrome reveals mechanisms causal to developmental recovery. Proceedings of the National Academy of Sciences 109: 17711-17716.

 

Won, Y., Ono, F., Ikeda, S. (2012) Characterization of Na⁺ and Ca²⁺ channels in zebrafish dorsal root ganglion neurons. PLoS ONE 7: e42602.

 

Papke, R., Ono, F., Stokes, C., Urban, J., Boyd, T. (2012) The nicotinic acetylcholine receptors of zebrafish and an evaluation of pharmacological tools used for their study. Biochemical Pharmacology 84:352-365.

 

Park, J., Ikeda, H, Ikenaga, T., Ono, F. (2012) Acetylcholine receptors enable the transport of rapsyn from the Golgi complex to the plasma membrane. Journal of Neuroscience 32:7356-7363.

 

Nakayama, S., Ikenaga, T., Kawakami, K., Ono, F., Hatta, K. (2012) A Gal4 gene trap line useful for studying the morphogenesis of craniofacial perichondrium, vascular endothelium-associated cells, floor plate, and dorsal midline radial glia during zebrafish development. Development Growth and Differentiation 54: 202-215.

 

Mongeon, R., Walogorsky, M., Urban, J., Mandel, G., Ono, F., Brehm, P. (2011) An acetylcholine receptor lacking both  and  subunits mediates transmission in zebrafish slow muscle synapses. Journal of General Physiology 138: 353-366.

 

Ikenaga, T., Urban, J., Gebhart, N., Hatta, K., Kawakami, K., Ono, F. (2011) Formation of the spinal network in zebrafish determined by domain-specific Pax genes. Journal of Comparative Neurology 519: 1562-1579.

 

Diep, C., Ma, D., Arora, N., Wingert, R., Bollig, F., Djordjevic, G., Lichman, B., Zhu, H., Ikenaga, T., Ono, F., Englert, C., Hukriede, N., Handin, R., Davidson, A. (2011) Identification of adult nephron progenitor cells capable of nephron formation and regeneration in zebrafish, Nature 470: 95-100.

 

Won, Y., Ono, F., Ikeda, S. (2011) Identification and modulation of voltage-gated Ca²⁺ current in zebrafish Rohon-Beard neurons, Journal of Neurophysiology 105: 442-453.

 

Epley, K., Urban, J., Ikenaga, T., and Ono, F. (2008) A modified acetylcholine receptor d-subunit enables a null mutant to survive beyond sexual maturation.  Journal of Neuroscience 28: 13223-13231.

 

Ono, F. (2008) An emerging picture of synapse formation: A balance of two opposing pathways. Science Signaling 1, pe3.

 

Ibanez-Tallon, I., Wen, H., Miwa, J.M., Xing, J., Tekinay, AB., Ono, F., Brehm, P., and Heintz, N. (2004) Tethering naturally occurring Peptide toxins for cell-autonomous modulation of ion channels and receptors in vivo. Neuron 43:305-11.

 

Luna, V., Wang, M., Ono, F., Gleason, M., Dallman, J., Mandel, G., and Brehm, P. (2004) Persistent electrical coupling and locomotory dysfunction in the zebrafish mutant shocked. Journal of Neurophysiology 92:2003-2009.

 

Ono, F., Mandel, G., and Brehm, P. (2004) Acetylcholine receptors direct rapsyn clusters to the neuromuscular synapse in zebrafish. Journal of Neuroscience 24:5475-5481.

 

Lefebvre, J.L., Ono, F., Puglielli, C., Saidner, G., Franzini-Armstrong, C., Brehm, P., and Granato, M. (2004) Increased neuromuscular activity causes axonal defects and muscle degeneration. Development 31:2605-2618.

 

Li, W., Ono, F., and Brehm, P. (2003) Optical measurements of presynaptic release in mutant zebrafish lacking postsynaptic receptors. Journal of Neuroscience 23:10467 - 10474.

 

Nakajo, K., Katsuyama, Y., Ono, F., Ohtsuka, Y., and Okamura, Y. (2003) Primary structure, functional characterization and developmental expression of the ascidian Kv4-class potassium channel. Neuroscience Research 45:59-70.

 

Ono, F., Shcherbatko, A., Higashijima, S., Mandel, G., and Brehm, P. (2002) The zebrafish motility mutant "twitch once" reveals new roles for rapsyn in synaptic function. Journal of Neuroscience 22:6491-8.

 

Okada, T., Katsuyama, Y., Ono, F., and Okamura, Y. (2002) The development of three identified motor neurons in ascidian embryo. Developmental Biology 244:278-92.

 

Ono, F., Higashijima, S., Shcherbatko, A., Fetcho, J.R., and Brehm, P. (2001) Paralytic zebrafish lacking acetylcholine receptors fail to localize rapsyn clusters to the synapse. Journal of Neuroscience 21:5439-5448.

 

Shchberbatko, A., Ono, F., Mandel, G., and Brehm, P. (1999) Voltage-dependent sodium channel function is regulated through membrane mechanics. Biophysical Journal 77:1945-1959.

 

Ono, F., Katsuyama, Y., Nakajo, K., and Okamura, Y. (1999) Subfamily-specific posttranscriptional mechanism underlies K+ channel expression in a developing neuronal blastomere. Journal of Neuroscience 19:6874-6886.

 

Okamura, Y., Ono, F. and Okagaki, R. (1997) Regulation of voltage-gated ion channels during ascidian embryogenesis. Developmental Neuroscience 19:23-24.

 

Okamura, Y., Ono, F. and Okagaki, R. (1996) Regulation of sodium channel gene expression by cell-specific interactions in the Ascidian embryo. Basic Neuroscience in Invertebrates 21-30.

 Okamura, Y., Ono, F., Okagaki, R., Chong, J.A., and Mandel, G. (1994) Neural expression of a sodium channel gene requires cell-specific interactions. Neuron 13:937-948. 

American Journal of Physiology, Alcohol, BBA, Brain Research, Canadian Journal of Zoology, Channels, Developmental Biology, Developmental Neurobiology, Disease Models & Mechanisms, F1000 Research,  FASEB Journal, Frontier in Neuroanatomy, Journal of Comparative Physiology B, Journal of Chemical Neuroanatomy, Journal of Drug and Alcohol Research, Journal of Medical Genetics, Journal of Neuroscience, Journal of Physiology, Molecular Endocrinology, Nature Communications, Neurochemical Research, Neuropharmacology, Neuroscience Letter, Neuroscience Research, PNAS, Reproductive Toxicology, Scientific Reports, Theranostics (journals)

 

European Research Council, The Netherlands Organization for Health Research and Development, Natural Sciences and Engineering Research Council of Canada, National Science Foundation, Japan Society for the Promotion of Science, National Institutes of Health (grants)

Research Map (in Japanese)  

https://researchmap.jp/onof

Tunesian TV

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Short lecture for high school students
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