大阪医科薬科大学病院
臨床研究センター

藤阪保仁　プロフィールと主な論文

 

専 門 領 域

新規抗がん剤早期開発（第I相試験）
腫瘍内科
呼吸器腫瘍

 

主な研究分野 　

がん免疫療法
分子標的治療薬を中心とした新規抗がん剤の早期開発臨床試験
固形がん薬物療法

 

関わった主な臨床試験

新規抗がん剤第I相試験（25薬剤以上）
肺癌・消化器癌・乳癌などの固形腫瘍における第Ⅱ・Ⅲ相試験、グローバル試験

 

略　歴

1998年　大阪医科大学医学部医学科卒業

1998年　大阪医科大学第１内科研修医

2000年　国立がんセンター中央病院　内科レジデント

2003年　国立がんセンター中央病院　がん専門修練医（内科・治療開発）

2005年　大阪医科大学附属病院呼吸器内科 助教

2009年　近畿大学医学部内科学教室腫瘍内科部門　講師

2013年　大阪医科大学附属病院　臨床治験センター　センター長
2017年　大阪医科大学附属病院　臨床研究センター　センター長　准教授
2020年　大阪医科大学附属病院　臨床研究センター　特別職務担当教員（教授）
2022年　大阪医科薬科大学医学部　内科学講座腫瘍内科学　教授

 

資格・学会活動 

医学博士

日本臨床腫瘍学会　協議員・専門医・指導医

日本呼吸器学会　呼吸器専門医・指導医

日本臨床薬理学会　指導医

日本サイコオンコロジー学会　代議員、　コミュニケーション技能訓練ファシリテーター

日本肺癌学会　評議員

日本腫瘍循環器学会　評議員

日本BNCT臨床腫瘍学会　理事

日本内科学会　評議員

 

主な論文

Lenvatinib in patients with advanced or metastatic thymic carcinoma (REMORA) : a multicentre, phase 2 trial
Authors	Journal
Jun Sato, Miyako Satouchi, Shoichi Itoh, Yusuke Okuma, Seiji Niho, Hidenori Mizugaki, Haruyasu Murakami, Yasuhito Fujisaka, Toshiyuki Kozuki, Kenichi Nakamura, Yukari Nagasaka, Mamiko Kawasaki, Tomoaki Yamada, Ryunosuke Machida, Aya Kuchiba, Yuichiro Ohe, Noboru Yamamoto	The Lancet. Oncology  21(6) 843 - 850  June, 2020
Exacerbation of autoimmune myocarditis by an immune checkpoint inhibitor is　dependent on its time of administration in mice
Authors	Journal
Kenjiro Tsuruoka, Shigeo Wakabayashi, Hirofumi Morihara, Ninso Matsunaga, Yasuhito Fujisaka, Isao Goto, Akihisa Imagawa, Michio Asahi	International journal of cardiology  13th April, 2020
Exploration of germline variants responsible for adverse events of crizotinib in anaplastic lymphoma kinase-positive non-small cell lung cancer by target-gene panel sequencing
Authors	Journal
Hidenori Mizugaki, Akinobu Hamada, Tatsuhiro Shibata, Fumie Hosoda, Hiromi Nakamura, Yusuke Okuma, Takehito Shukuya, Shigeki Umemura, Atsushi Horiike, Tomoya Fukui, Yoshihito Kogure, Haruko Daga, Yoshiko Urata, Kazuhiko Yamada, Sho Saeki, Yasuhito Fujisaka, Yukiko Nakamura, Mitsuo Sato, Tatsuya Yoshida, Takamasa Hotta, Satoshi Oizumi, Yasuhiro Fujiwara, Yuichiro Ohe, Yutaka Fujiwara	Lung cancer (Amsterdam, Netherlands) 128 20 - 25 February, 2020
An early clinical trial of Salirasib, an oral RAS inhibitor, in Japanese patients with relapsed/refractory solid tumors
Authors	Journal
Junji Furuse, Takayasu Kurata, Naohiro Okano, Yasuhito Fujisaka, Daisuke Naruge, Toshio Shimizu, Hiroshi Kitamura, Tsutomu Iwasa, Fumio Nagashima, Kazuhiko Nakagawa	Cancer chemotherapy and pharmacology 82(3) 511 - 519 September, 2018
Phase 3 study of ceritinib vs chemotherapy in ALK-rearranged NSCLC patients previously treated with chemotherapy and crizotinib (ASCEND-5): Japanese subset
Authors	Journal
Katsuyuki Kiura, Fumio Imamura, Hiroshi Kagamu, Shingo Matsumoto, Toyoaki Hida, Kazuhiko Nakagawa, Miyako Satouchi, Isamu Okamoto, Mitsuhiro Takenoyama, Yasuhito Fujisaka, Takayasu Kurata, Masayuki Ito, Kota Tokushige, Ben Hatano, Makoto Nishio	Japanese journal of clinical oncology 48(4) 367 - 375 1st April, 2020
Retrospective Study of Treatment for Postoperative Local Recurrence of Lung Cancer
Authors	Journal
Kenjiro Tsuruoka, Keiji Miyoshi, Ninso Matsunaga, Takahiko Nakamura, Shuhei Yoshida, Yousuke Tamura, Masafumi Imanishi, Soichiro Ikeda, Yasuhito Fujisaka, Isao Goto	JOURNAL OF THORACIC ONCOLOGY  12(1) S682 - S682  January, 2017
A Retrospective Analysis of the Chemotherapy for 'Very Old' Patients Aged 80 Years and Order with Advanced Lung Cancer
Authors	Journal
Yosuke Tamura, Yasuhito Fujisaka, Keiji Miyoshi, Ninso Matsunaga, Kenjiro Tsuruoka, Takahiko Nakamura, Shuhei Yoshida, Tetsufumi Kawaguchi, Masafumi Imanishi, Soichiro Ikeda, Isao Goto	JOURNAL OF THORACIC ONCOLOGY 12(1) S914 - S915 January, 2017
Phase I/II study of nab-paclitaxel (nab-P) with cisplatin (C) and thoracic radiation (TRT) in patients with locally advanced NSCLC: Safety results of phase I part
Authors	Journal
Hidetoshi Hayashi, Masakazu Ogura, Takashi Niwa, Satoshi Ikeo, Takashi Yokoi, Yoshitaro Torii, Kunio Okamoto, Yosuke Tamura, Kaoru Tanaka, Yasuhito Fujisaka, Isao Goto, Hiroyasu Kaneda, Takayasu Kurata, Hiroshige Yoshioka, Kazuhiko Nakagawa	JOURNAL OF CLINICAL ONCOLOGY 34(15) May,2016
Small-cell Lung Cancer in a Young Adult Nonsmoking Patient with Ectopic Adrenocorticotropin (ACTH) Production
Authors	Journal
Masahiko Aoki, Yasuhito Fujisaka, Satoshi Tokioka, Ai Hirai, Yujiro Henmi, Yosuke Inoue, Ken Narabayashi, Takeshi Yamano, Yosuke Tamura, Yutaro Egashira, Kazuhide Higuchi	Internal medicine (Tokyo, Japan) 55(10) 1337 -9 2016
A Retrospective Analysis of Adjuvant Chemotherapy in Patients with Completely Resected SCLC
Authors	Journal
Yosuke Tamura, Yasuhito Fujisaka, Takahito Nakamura, Hiroyuki Tsuji, Ninso Matsunaga, Tetsufumi Kawaguchi, Masashi Imanishi, Syuhei Yoshida, Keiji Miyoshi, Soichiro Ikeda, Isao Goto, Toshiaki Hanafusa	JOURNAL OF THORACIC ONCOLOGY 10(9) S744 - S744 September, 2015
Large cell neuroendocrine carcinoma of the lung withcancer-associated retinopathy
Authors	Journal
Takahiko Nakamura, Yasuhito Fujisaka, Yosuke Tamura, Hiroyuki Tsuji, Ninso Matsunaga, Shuhei Yoshida, Masafumi Imanishi, Kazuhiko Fujita, Soichiro Ikeda, Hidehiro Oku, Isao Goto, Tsunehiko Ikeda, Toshiaki Hanafusa	Case Reports in Oncology 8(1) 153 - 158 22 May, 2015
Phase I study of amatuximab, a novel monoclonal antibody to mesothelin, in Japanese patients with advanced solid tumors
Authors	Journal
Yasuhito Fujisaka, Takayasu Kurata, Kaoru Tanaka, Toshihiro Kudo, Kunio Okamoto, Junji Tsurutani, Hiroyasu Kaneda, Isamu Okamoto, Masayuki Namiki, Chifumi Kitamura, Kazuhiko Nakagawa	Investigational new drugs 33(2) 380 - 8 April, 2015