学位

　

大阪医科薬科大学

令和5年度

50.: 石郷岡岳　博士（医学）
Ishigooka G, Mizuno H, Oosuka S, Jin D, Takai S, Kida T.
Effects of angiotensin receptor blockers on streptozotocin-induced diabetic cataracts. J Clin Med. 12(20), 6627, 2023.

49.: 西村尋眸　博士（医学）
Nishimura H, Jin D, Kinoshita I, Taniuchi M, Higashino M, Terada T, Takai S, Kawata R.
Increased chymase-positive mast cells in high-grade mucoepidermoid carcinoma of the parotid gland. Int J Mol Sci. 24(9), 8267, 2023.

令和4年度

48.: 猪俣陽介　博士（医学）
Inomata Y, Oh JW, Jin D, Taniguchi K, Sugito N, Kawaguchi N, Hirokawa F, Lee SW, Akao Y, Takai S, Kim KP, Uchiyama K.
miR-122-5p downregulation activities glycolysis via PKM2 in Kupper cells of rat and mouse models of non-alcoholic steatohepatitis. Int J Mol Sci. 23(9), 5230, 2022.

47.: 藤田恭史　博士（医学）
Fujita Y, Jin D, Mimura M, Sato Y, Takai S, Kida T.
Activation of mast-cell-derived chymase in the lacrimal glands of patients with IgG4-related ophthalmic disease. Int. J. Mol. Sci. 23(5), 2556, 2022.

46.: 木下一太　博士（医学）
Kinoshita I, Jin D, Higashino M, Terada T, Kurisu Y, Takai S, Kawata R.
Increase in chymase-positive mast cells in recurrent pleomorphic adenoma and carcinoma ex pleomorphic adenoma of the parotid gland. Int J Mol Sci. 22(23), 12613, 2021.

45.: 犬飼隆之　博士（医学）
犬飼隆之.
Structure Based Drug Design（SBDD）を活用した分子設計による種差克服を目指した新規キマーゼ阻害剤の創製. 大阪医科薬科大学医学会雑誌 81(1-2), 85-95, 2022.

44.: 庫本達　博士（医学）
Kuramoto T, Jin D, Komeda K, Taniguchi K, Hirokawa F, Takai S, Uchiyama K.
Chymase as a novel therapeutic target in acute pancreatitis. Int J Mol Sci. 22(22), 12313, 2021.

43.: 廣川貴久　博士（医学）
Hirokawa T, Horie T, Fukiyama Y, Mimura M, Takai S, Kida T, Oku H.
Roscovitine, a cyclin-dependent kinase-5 inhibitor, decreases phosphorylated tau formation and death of retinal ganglion cells of rats after optic nerve crush. Int J Mol Sci. 22(15), 8096, 2021.

大阪医科薬科大学

令和3年度

42.: 寺井健太郎　博士（医学）
Terai K, Jin D, Watase K, Imagawa A, Takai S.
Mechanism of albuminuria reduction by chymase inhibition in diabetic mice. Int J Mol Sci. 21(19), 7347, 2020.

41.: 根元栄美佳　博士（医学）
Nemoto E, Kojima S, Sugiyama T, Jin D, Takai S, Maeda M, Kohmoto R, Ueki M, Oku H, Ikeda T.
Effects of regorafenib, a multi-kinase inhibitor, on conjunctival scarring in a canine filtration surgery model in comparison with mitomycin-C. Int J Mol Sci. 20(1), 63, 2019.

40.: 熊谷悦子　博士（医学）
Kumagai E, Hosohata K, Furumachi K, Takai S.
Effectiveness of monitoring free carnitine levels for L-carnitine supplementation in homodialysis patients to maintain carnitine sufficiency and nutritional factors. Ther Apher Dial. 25(2), 595-606, 2021.

大阪医科大学

令和2年度

39.: 渡瀨謙仁　博士（医学）
Watase K, Jin D, Terai K, Kaneyama T, Nakakura H, Shibahara N, Arima S, Takai S.
Possible roles of periostin in the formation of hemodialysis vascular access stenosis after polytetrafluoroethylene graft implantation in dogs. Int J Mol Sci. 21(9), 3251, 2020.

平成31年度(令和1年度）

38.: サンフォード（大関）舞子　博士（医学）
Ozeki M, Jin D, Miyaoka Y, Masybuchi S, Hirokawa F, Hayashi M, Takai S, Uchiyama K.
Comparison of a chymase inhibitor and hyaluronic acid/carboxymethylcellulose (Seprafilm) in a novel peritoneal adhesion model in rats. Plos One. 14, e211438, 2019.

37.: 奥田吉隆　博士（医学）
Okuda Y, Fukumoto M, Horie T, Oku H, Takai S, Nakanishi T, Matsuzaki K, Tsujimoto H, Ikeda T.
Periocular injection of candesartan-PLGA micrparticles inhibits laser-induced experimental choroidal neovascularization. Clin Ophthalmol. 13, 87-93, 2019.

36.: 中尾謙太　博士（医学）
Nakao K, Fijiwara A, Komasawa N, Jin D, Kitano M, Matsunami S, Takai S, Ito S, Minami T.
Yokukansan alleviates cancer pain by suppressing, matrix metalloproteinase-9 in a mouse bone metastasis model. Evid based Complement Alternat Med. 2019, 2956920, 2019.

平成30年度

35.: 平原一郎　博士（医学）
平原一郎
ラット腹膜傷害におけるメチルグリオキサールによるグルタミン代謝の亢進. 大阪医科大学雑誌. 77(1-2), 70-79, 2018.

平成29年度

34.: 宮岡雄太　博士（医学）
Miyaoka Y, Jin D, Tashiro K, Komeda K, Masubuchi S, Hirokawa F, Hayshi M, Takai S, Uchiyama K.
Chymase inhibitor prevents the development and progression of non-alcoholic steatohepatitis in rats fed a high-fat and high-cholesterol diet. J Pharmacol Sci. 134(3), 139-146, 2017.

33.: 前田（三木）美智子　博士（医学）
Maeda M, Kojima S, Sugiyama T, Jin D, Takai S, Oku H, Kohmoto R, Ueki M, Ikeda T.
Effects of gelatin hydrogel containing anti-transforming growth factor-β antibody in a canine filtration surgery model. Int J Mol Sci. 18(5), 985, 2017.

平成28年度

32.: 田尻健介　博士（医学）
Tajiri K, Sugiyama T, Jin D, Takai S, Ikeda T.
Suppression of conjunctival scarring by chymase inhibitor in a canine symblepharon model. Int J Ophthalmol Eye Res. S7-002, 6-12, 2016.

平成27年度

31.: 大住渉　博士（医学）
Osumi W, Jin D, Imai Y, Tashiro K, Li ZL, Otsuki Y, Maemura K, Komeda K, Hirokawa F, Hayashi M, Takai S, Uchiyama K.
Recombinant human soluble thrombomodulin improved lipopolysaccharide/D-galactosamine-induced acute liver failure in mice. J Pharmacol Sci. 129, 233-239, 2015.

平成25年度

30.: 今井義朗　博士（医学）
Imai Y, Takai S, Jin D, Komeda K, Tashiro K, Li ZL, Otsuki Y, Okamura H, Hayashi M, Uchiyama K.
Chymase inhibition attenuates lipopolysaccharide/d-galactosamine-induced acute liver failure in hamsters. Pharmacology. 93, 47-56, 2014.

平成24年度

29.: 鱒渕真介　博士（医学）
Masubuchi S, Takai S, Jin D, Tashiro K, Komeda K, Li ZL, Otsuki Y, Okamura H, Hayashi M, Uchiyama K.
Chymase inhibitor ameliorates hepatic steatosis and fibrosis on established non-alcoholic steatohepatitis in hamsters fed a methionine- and choline-deficient diet. Hepatol Res. 43, 970-978, 2013.

28.: 藤阪智弘　博士（医学）
Fujisaka T, Hoshiga M, Hotchi J, Takeda Y, Jin D, Takai S, Hanafusa T, Ishizaka N.
Angiotensin II promotes aortic valve thickening independent of elevated blood pressure in apolipoprotein-E deficient mice. Atherosclerosis. 226, 82-87, 2013.

平成21年度

27.: 福本雅格　博士（医学）
Fukumoto M, Takai S, Ishizaki E, Sugiyama T, Oku H, Jin D, Sakaguchi M, Sakonjo H, Ikeda T, Miyazaki M.
Involvement of angiotensin II-dependent vascular endothelial growth factor gene expression via NADPH oxidase in the retina in a type 2 diabetic rat model. Curr Eye Res. 33, 885-891, 2008.

26.: 田代圭太郎　博士（医学）
Tashiro K, Takai S, Jin D, Yamamoto H, Komeda K, Hayashi M, Tanaka K, Tanigawa N, Miyazaki M.
Chymase inhibitor prevents the nonalcoholic steatohepatitis in hamsters fed a methionine- and choline-deficient diet. Hepatol Res. 40, 514-523, 2010.

25.: 柿本一城　博士（医学）
Kakimoto K, Takai S, Murano M, Ishida K, Yoda Y, Inoue T, Jin D, Umegaki E, Higuchi K.
Significance of chymase-dependent matrix metalloproteinase-9 activation on indomethacin-induced small intestinal damages in rats. J Pharmacol Exp Ther. 332, 684-689, 2010.

平成20年度

24.: 井上奈緒　博士（医学）
Inoue N, Muramatsu M, Jin D, Takai S, Hayashi T, Katayama H, Kitaura Y, Tamai H, Miyazaki M.
Effects of chymase inhibitor on angiotensin II-induced abdominal aortic aneurysm development in apolipoprotein E-deficient mice. Atherosclerosis. 204, 359-364, 2009.

23.: 天野信行　博士（医学）
Amano N, Takai S, Jin D, Ueda K, Miyazaki M.
Possible roles of mast cell-derived chymase for skin rejuvenation. Lasers Med Sci. 24, 223-229, 2009.

平成19年度

22.: 米田浩二　博士（医学）
Komeda K, Jin D, Takai S, Hayashi M, Takeshita A, Shibayama Y, Tanigawa N, Miyazaki M.
Significance of chymase-dependent angiotensin II formation in the progression of human liver fibrosis. Hepatol Res. 38, 501-510, 2008.

21.: 石田久美　博士（医学）
Ishida K, Takai S, Murano M, Nishikawa T, Inoue T, Murano N, Inoue N, Jin D, Umegaki E, Higuchi K, Miyazaki M.
Role of chymase-dependent matrix metalloproteinase-9 activation in mice with dextran sodium sulfate-induced colitis. J Pharmacol Exp Ther. 324, 422-426, 2008.

20.: 石﨑英介　博士（医学）
Ishizaki E, Takai S, Ueki M, Maeno T, Maruichi M, Sugiyama T, Oku H, Ikeda T, Miyazaki M.
Correlation between angiotensin-converting enzyme, vascular endothelial growth factor, and matrix metalloproteinase-9 in the vitreous of eyes with diabetic retinopathy. Am J Ophthalmol. 141, 129-134, 2006.

平成18年度

19.: 古林圭一　博士（医学）
Furubayashi K, Takai S, Jin D, Muramatsu M, Ibaraki T, Nishimoto M, Fukumoto H, Katsumata T, Miyazaki M.
The significance of chymase in the progression of abdominal aortic aneurysms in dogs. Hypertens Res. 30, 349-357, 2007.

18.: 田中秀一　博士（医学）
Tanaka H, Takai S, Jin D, Furubayashi K, Inoue N, Kajimoto Y, Miyatake S, Kuroiwa T, Miyazaki M.
Inhibition of matrix metalloproteinase-9 activity by trandolapril after middle cerebral artery occlusion in rats. Hypertens Res. 30, 469-475, 2007.

17.: 岸勘太　博士（医学）
Kishi K, Jin D, Takai S, Muramatsu M, Katayama H, Tamai H, Miyazaki M.
Role of chymase-dependent angiotensin II formation in monocrotaline-induced pulmonary hypertensive rats. Pediatr Res. 60, 77-82, 2006.

16.: 梅川俊義　博士（医学）
梅川俊義
ハムスター子宮内膜症モデルの臓器癒着における肥満細胞の関与. 大阪医科大学雑誌. 66, 12-19, 2007.

15.: 茨木利彦　博士（医学）
Ibaraki T, Muramatsu M, Takai S, Jin D, Maruyama H, Orino T, Katsumata T, Miyazaki M.
The relationship of tryptase- and chymase-positive mast cells to angiogenesis in stage I non-small cell lung cancer. Eur J Cardiothorac Surg. 28, 617-621, 2005.

14.: 有城久美子　博士（医学）
Arishiro K, Hoshiga M, Negoro N, Jin D, Takai S, Miyazaki M, Ishihara T, Hanafusa T.
Angiotensin receptor-1 blocker inhibits atherosclerotic changes and endothelial disruption of the aortic valve in hypercholesterolemic rabbits. J Am Coll Cardiol. 49, 1482-1489, 2007.

平成17年度

13.: 近藤圭策　博士（医学）
Kondo K, Muramatsu M, Okamoto Y, Jin D, Takai S, Tanigawa N, Miyazaki M.
Expression of chymase-positive cells in gastric cancer and its correlation with the angiogenesis. J Surg Oncol. 93, 36-42, 2006.

12.: 桐村和義　博士（医学）
Kirimura K, Takai S, Jin D, Muramatsu M, Kishi K, Yoshikawa K, Nakabayashi M, Mino Y, Miyazaki M.
Role of chymase-dependent angiotensin II formation in regulating blood pressure in spontaneously hypertensive rats. Hypertens Res. 28, 457-464, 2005.

平成16年度

11.: 丸一みどり　博士（医学）
丸一みどり
イヌ緑内障手術後の濾過胞瘢痕化におけるキマーゼの役割. 大阪医科大学雑誌. 63, 23-31, 2004.

10.: 奥村謙一　博士（医学）
Okumura K, Jin D, Takai S, Miyazaki M.
Beneficial effects of angiotensin-converting enzyme inhibition in adriamycin-induced cardiomyopathy in hamsters. Jpn J Pharmacol. 88, 183-188, 2002.

平成15年度

9.: 常深孝太郎　博士（医学）
Tsunemi K, Takai S, Nishimoto M, Yuda A, Jin D, Sakaguchi M, Sawada Y, Asada K, Kondo K, Sasaki S, Miyazaki M.
Lengthy suppression of vascular proliferation by a chymase inhibitor in dog grafted veins. J Thorac Cardiovasc Surg. 124, 621-625, 2002.

8.: 阪口眞人　博士（医学）
Sakaguchi M, Yamamoto D, Takai S, Jin D, Taniguchi M, Baba K, Miyazaki M.
Inhibitory mechanism of daphnodorins for human chymase. Biochem Biophys Res Commun. 283, 831-836, 2001.

平成14年度

7.: 坂口仁志　博士（医学）
Sakaguchi H, Takai S, Sakaguchi M, Sugiyama T, Ishihara T, Yao Y, Miyazaki M, Ikeda T.
Chymase and angiotensin converting enzyme activities in a hamster model of glaucoma filtering surgery. Curr Eye Res. 24, 325-331, 2002.

6.: 髙尾和正　博士（医学）
Takao K, Takai S, Ishihara T, Mita S, Miyazaki M.
Isolation of chymase complexed with physiological inhibitor similar to secretory leukocyte protease inhibitor (SLPI) from hamster cheek pouch tissues. Biochim Biophys Acta. 1545, 146-152, 2001.

5.: 岡本健　博士（医学）
Okamoto K, Takai S, Sasaki S, Miyazaki M.
Trandolapril reduces infarction area after middle cerebral artery occlusion in rats. Hypertens Res. 25, 583-588, 2002.

平成13年度

4.: 岡本由記子　博士（医学）
Okamoto Y, Takai S, Yamada M, Miyazaki M.
Chymase inhibitors may prevent postoperative adhesion formation. Fertil Steril. 77, 1044-1048, 2002.

3.: 岩本勇作　博士（医学）
Iwamoto Y, Song K, Takai S, Yamada M, Jin D, Sakaguchi M, Ueda H, Katsuoka Y, Miyazaki M.
Multiple pathways of angiotensin I conversion and their functional role in the canine penile corpus cavernosum. J Pharmacol Exp Ther. 298, 43-48, 2001.

2.: 西本昌義　博士（医学）
Nishimoto M, Takai S, Sawada Y, Yuda A, Kondo K, Yamada M, Jin D, Sakaguchi M, Asada K, Sasaki S, Miyazaki M.
Chymase-dependent angiotensin 2 formation in the saphenous vein versus the internal thoracic artery. J Thorac Cardiovasc Surg. 121, 729-734, 2001.

平成12年度

1.: 湯田淳　博士（医学）
Yuda A, Takai S, Jin D, Sawada Y, Nishimoto M, Matsuyama N, Asada K, Kondo K, Sasaki S, Miyazaki M.
Angiotensin II receptor antagonist, L-158,809, prevents intimal hyperplasia in dog grafted veins. Life Sci. 68, 41-48, 2000.

他大学

平成31年度(令和1年度）

6.: 寺西裕一（大阪市立大学)　博士（医学）
Teranishi Y, Jin D, Takano S, Sunami K, Takai S
Decrease in number of mast cells in resected nasal polyps as an indicator for postoperative recurrence of chronic rhinosinusitis. Immun Inflamm Dis. 7, 191-200, 2019.

平成23年度

5.: 猿倉薫子（徳島大学)　博士（栄養学）
Sarukura N, Kogirima M, Takai S, Kitamura Y, Kalubi B, Yamamoto S, Takeda N.
Dietary zinc intake and its effects on zinc nutrition in healthy Japanese living in the central area of Japan. J Med Invest. 58, 203-209, 2011.

平成18年度

4.: 森原潔（京都府立医科大学）　博士（医学）
Morihara K, Takai S, Takenaka H, Sakaguchi M, Okamoto Y, Morihara T, Miyazaki M, Kishimoto S.
Cutaneous tissue angiotensin-converting enzyme may participate in pathologic scar formation in human skin. J Am Acad Dermatol. 54: 251-257, 2006.

平成17年度

3.: 金光ひでお（京都大学）　博士（医学）
Kanemitsu H, Takai S, Tsuneyoshi H, Nishina T, Yoshikawa K, Miyazaki M, Ikeda T, Komeda M.
Chymase inhibition prevents cardiac fibrosis and dysfunction after myocardial infarction in rats. Hypertens Res. 29, 57-64, 2006.

平成15年度

2.: 曽我欣治（京都大学）　博士（医学）
Soga Y, Takai S, Koyama T, Okamoto Y, Ikeda T, Nishimura K, Miyazaki M, Komeda M.
Attenuation of adhesion formation after cardiac surgery with a chymase inhibitor in a hamster model. J Thorac Cardiovasc Surg. 127, 72-78, 2004.

平成13年度

1.: 田辺裕子（聖マリアンナ医科大学）　博士（医学）
田辺裕子, 相馬良直, 高井真司, 宮崎瑞夫, 溝口昌子
ヒト皮膚微小血管内皮細胞とヒト皮膚線維芽細胞に対するキマーゼの作用について. 日本皮膚科学会雑誌　112, 239-246, 2002.